Dr. Jennifer Orthmann-Murphy, MD, PhD

Chair, SHF Medical & Scientific Advisory Council

Assistant Professor of Neurology, Perelman School of Medicine at the University of Pennsylvania

Co-Director of the Agespan Fellowship on MS/Neuroinflammatory Disorders, Perelman School of Medicine


Jennifer Orthmann-Murphy, MD, PhD is an assistant professor of Neurology at the University of Pennsylvania. Dr. Orthmann-Murphy started her lab at Penn in October 2018 to study the role of glial cells in myelin disorders. She also sees patients with multiple sclerosis and leads an ‘Undiagnosed White Matter Disorders’ neurogenetics clinic. She is co-director of the Age-Span Fellowship in Multiple Sclerosis and Neuroinflammatory Disorders, and is associated with the Neuroscience Graduate Group at Penn. Dr. Orthmann-Murphy’s expertise includes Demyelinating Disease Leukodystrophy, Multiple Sclerosis (MS) Myelitis Neurogenetics Neuroinflammatory Disorders, Neuromyelitis Optica (NMO) Spectrum Disorder.

The Orthmann-Murphy Lab studies the role of glial cells in acquired and inherited myelin disorders at the University of Pennsylvania Perelman School of Medicine and was awarded a grant from the National Multiple Sclerosis Society, to support research on astrocyte contributions to cortical remyelination.